Scientific Program (confirmed speakers and chairs)
Scientific sessions cover a wide range of topics in the P-type ATPase field with presentations by world leading scientists.
Opening Remarks: | Giuseppe Inesi | California Pacific Medical Center |
Special Lecture: | Toshio Ando | Univ. of Kanazawa |
Nano-visualization of protein molecules in action by high-speed AFM |
Keynote Lectures: | Poul Nissen | Univ. of Aarhus |
Chikashi Toyoshima | Univ. of Tokyo |
Na,K-ATPase and H,K-ATPase 1 (structure-function relationship)
September 25 (Mon), Oral session 1
Chair: Flemming Cornelius | Univ. of Aarhus |
Kazuhiro Abe | Univ. of Nagoya |
Structural and functional analysis of gastric H+,K+-ATPase |
Ronald Clarke | Univ. of Sydney |
Role of electrostatic stabilisation in the mechanism and regulation of Na+,K+- and H+,K+-ATPases |
David Gadsby | Univ. of Rockfeller canceled |
Proton import by Na/K pumps: evolutionary limit, or hybrid function possibly linked to neurological disorders? |
Haruo Ogawa | Univ. of Tokyo |
X-ray crystallographic study of Na,K-ATPase in complex with cardiotonic steroids |
Bente Vilsen | Univ. of Aarhus |
New aspects of sodium and potassium binding of Na,K-ATPase |
Mads Schak Toustrup-Jensen | Univ. of Aarhus |
Structural Elements Important for Oligomycin Inhibition of the Na+,K+-ATPase |
Pablo Artigas | Univ. of Texas Tech |
Effect of two asparagine-lysine substitutions found in the Na/K pump isoform unregulated in hyper salinity-adapted brine shrimp |
Joshua R. Berlin | Univ. of Rutgers |
Free energy calculations suggest a mechanism for Na+/K+-ATPase ion selectivity |
Na,K-ATPase and H,K-ATPase 2 (physiology and diseases)
September 28 (Thu), Oral session 5
Chair: Kathleen Sweadner | Massachusetts General Hospital |
Anita Aperia | Karolinska Institute |
Neuronal Na;K-ATPase in health and disease |
Minako Hoshi | Univ. of Kyoto |
Na, K-ATPase ƒ¿3 and Alzheimer's Disease |
Steve Karlish | Weizmann Institute |
Specific interactions of Na,K-ATPase with lipids - physiological rationale and role in diseases |
Kiyoshi Kawakami | Univ. of Jichi Medical |
Atp1a2-deficient mice as a model of familial hemiplegic migraine |
Helge Rasmussen | Univ. of Sydney |
Na-K pump stimulation and FXYD3 suppression as treatment objectives in heart failure and cancer |
Zijian Xie (Represented by Sandrine Pierre) Univ. of Marshall |
Na/K-ATPase-mediated Signal Transduction in Animal Physiology and Disease Progression |
Gustavo Blanco | Univ. of Kansas |
Relative contribution of Na,K-ATPase ƒ¿4 and Na,K-ATPase ƒ¿1 isotermas to sperm motility |
Evgeny Akkuratov | Royal Institute of Technology |
Translational study on disease associated with mutation in ATP1A3 gene |
Ca-ATPase and other P2-ATPases
September 26 (Tue), Oral session 2
Chair: Giuseppe Inesi | California Pacific Medical Center |
Rajini Rao | Univ. of Johns Hopkins |
Tumor Suppressor Role of SPCA2 in Breast Cancer |
Hiroshi Suzuki | Univ. of Asahikawa Medical |
Structure/function of Ca-ATPase revealed by mutations, kinetics, and structural analyses of reaction intermediates |
David D. Thomas | Univ. of Minnesota |
Therapeutic Discovery Based on SERCA Structural Dynamics |
Jilin Chen | KU Leuven |
Regulation of the secretory pathway Ca2+ ATPase SPCA1a and SPCA2 by Ca2+ and Orai1 |
Pump regulators
September 29 (Fri), Oral session 8
Chair: Howard S. Young | Univ. of Alberta |
Muthu Periasamy | Sunford Burnham Prebys, Medical Discovery Institute canceled |
Seth Robia | Loyola Univ. Chicago |
Structure, Affinity, and Stoichiometry of Micropeptide Regulatory Complexes |
Howard S. Young | Univ. of Alberta |
Conformational memory in phospholamban regulation of the sarcoplasmic reticulum calcium pump SERCA |
L. Michael Espinoza-Fonseca | Univ. of Minnesota |
Structural mechanism for SERCA uncoupling by sarcolipin through the lens of the computational microscope |
Chia-chi Liu | Univ. of Sydney |
Silencing FXYD3 Protein in Human Pancretaic Cancer Cells Enhances Cytotoxic Effect of Doxorubicin |
Alexander V Chibalin | Karolinska Institute |
The role of FXYD1 protein in energy metabolism |
P4-ATPase (Flippase) - structure, function, cell biology and disease
September 27 (Wed), Oral session 3
Chair: Todd R. Graham | Univ. of Vanderbilt |
Jens Peter Andersen | Univ. of Aarhus |
Mutagenesis of ATP8A2: On the track of the lipid transport pathway. |
Todd R. Graham | Univ. of Vanderbilt |
Novel substrates and transport mechanisms for P4-ATPases |
Guillaume Lenoir | Institute for Integrative Biology of the Cell |
Regulation of a yeast P4-ATPase by its terminal extensions |
Katsumori Segawa | Univ. of Osaka |
Function and regulation of plasma membrane phospholipid flippases |
Hye-won Shin | Univ. of Kyoto |
Specific substrates for P4-ATPases and their regulation in mammalian cells |
Tomoki Naito | Univ. of Kyoto |
Identification of mammalian glucosylceramide flippase and its transport mechanism |
Yuki Hara | Univ. of Kyoto |
The role of phospholipid flippase in myotube formation |
Other P-type ATPases including P1, P5-ATPases
September 29 (Fri), Oral session 7
Chair: Jack Kaplan | Univ. of Illinois at Chicago |
Jose M. Arguello | Worcester Polytechnic Institute |
Expanding the repertoire of P1B-ATPases: Mycobacteria Fe2+-ATPases |
Svetlana Lutsenko | Univ. of Johns Hopkins |
ATP7A and ATP7B have distinct function in the cellular copper homeostasis |
Michael Palmgren | Univ. of Copenhagen |
Evolution and role of zinc pumps in eukaryotes |
David Stokes | Univ. of New York |
Structure and Mechanism of the KdpFABC pump from E. coli |
Peter Vangheluwe | KU Leuven |
Novel P-type ATPases as gatekeepers of neuronal health |
Christina Gronberg | Univ. of Copenhagen |
Ion-binding to purified and functional human copper transporting P-type ATPase ATP7B |
J. Preben Morth | Univ. of Oslo |
Functional characterization of the first primary active magnesium transporter |
Molecular simulations - towards quantitative understanding
September 27 (Wed), Oral session 4
Chair: Yuji Sugita | RIKEN |
Himanshu Khandelia | Univ. of Southern Denmark |
The elusive proton in ion pumps |
Yuji Sugita | RIKEN |
Molecular Dynamics Simulations of Conformational Changes in SR Ca-ATPase |
Benoit Roux | Univ. of Chicago |
Molecular Dynamics Studies of P-type ATPase Ion Pumps |
Emerging technologies
September 28 (Thu), Oral session 6
Chair: Takayuki Nishizaka | Univ. of Gakushuin |
Takayuki Nishizaka | Univ. of Gakushuin |
Application of single-molecule techniques to supramolecular machinery in bacteria and archaea |
Rikiya Watanabe | Univ. of Tokyo |
Novel microsystems for highly sensitive analysis of transport proteins |
Milena Laban | Univ. of Aarhus |
Towards a structure of the yeast lipid flippase, Drs2p/Cdc50p, using cryo-electron microscopy |
Poster Sessions