Scientific Program (confirmed speakers and chairs)

Scientific sessions cover a wide range of topics in the P-type ATPase field with presentations by world leading scientists.

Opening Remarks:Giuseppe InesiCalifornia Pacific Medical Center
Special Lecture:Toshio AndoUniv. of Kanazawa
Nano-visualization of protein molecules in action by high-speed AFM
Keynote Lectures:Poul NissenUniv. of Aarhus
Chikashi ToyoshimaUniv. of Tokyo

Na,K-ATPase and H,K-ATPase 1 (structure-function relationship)
September 25 (Mon), Oral session 1

Chair: Flemming CorneliusUniv. of Aarhus
Kazuhiro AbeUniv. of Nagoya
Structural and functional analysis of gastric H+,K+-ATPase
Ronald ClarkeUniv. of Sydney
Role of electrostatic stabilisation in the mechanism and regulation of Na+,K+- and H+,K+-ATPases
David GadsbyUniv. of Rockfeller canceled
Proton import by Na/K pumps: evolutionary limit, or hybrid function possibly linked to neurological disorders?
Haruo OgawaUniv. of Tokyo
X-ray crystallographic study of Na,K-ATPase in complex with cardiotonic steroids
Bente VilsenUniv. of Aarhus
New aspects of sodium and potassium binding of Na,K-ATPase
Mads Schak Toustrup-JensenUniv. of Aarhus
Structural Elements Important for Oligomycin Inhibition of the Na+,K+-ATPase
Pablo ArtigasUniv. of Texas Tech
Effect of two asparagine-lysine substitutions found in the Na/K pump isoform unregulated in hyper salinity-adapted brine shrimp
Joshua R. BerlinUniv. of Rutgers
Free energy calculations suggest a mechanism for Na+/K+-ATPase ion selectivity

Na,K-ATPase and H,K-ATPase 2 (physiology and diseases)
September 28 (Thu), Oral session 5

Chair: Kathleen SweadnerMassachusetts General Hospital
Anita AperiaKarolinska Institute
Neuronal Na;K-ATPase in health and disease
Minako HoshiUniv. of Kyoto
Na, K-ATPase 3 and Alzheimer's Disease
Steve KarlishWeizmann Institute
Specific interactions of Na,K-ATPase with lipids - physiological rationale and role in diseases
Kiyoshi KawakamiUniv. of Jichi Medical
Atp1a2-deficient mice as a model of familial hemiplegic migraine
Helge RasmussenUniv. of Sydney
Na-K pump stimulation and FXYD3 suppression as treatment objectives in heart failure and cancer
Zijian Xie (Represented by Sandrine Pierre) Univ. of Marshall
Na/K-ATPase-mediated Signal Transduction in Animal Physiology and Disease Progression
Gustavo BlancoUniv. of Kansas
Relative contribution of Na,K-ATPase 4 and Na,K-ATPase 1 isotermas to sperm motility
Evgeny AkkuratovRoyal Institute of Technology
Translational study on disease associated with mutation in ATP1A3 gene

Ca-ATPase and other P2-ATPases
September 26 (Tue), Oral session 2

Chair: Giuseppe InesiCalifornia Pacific Medical Center
Rajini RaoUniv. of Johns Hopkins
Tumor Suppressor Role of SPCA2 in Breast Cancer
Hiroshi SuzukiUniv. of Asahikawa Medical
Structure/function of Ca-ATPase revealed by mutations, kinetics, and structural analyses of reaction intermediates
David D. ThomasUniv. of Minnesota
Therapeutic Discovery Based on SERCA Structural Dynamics
Jilin ChenKU Leuven
Regulation of the secretory pathway Ca2+ ATPase SPCA1a and SPCA2 by Ca2+ and Orai1

Pump regulators
September 29 (Fri), Oral session 8

Chair: Howard S. YoungUniv. of Alberta
Muthu PeriasamySunford Burnham Prebys, Medical Discovery Institute canceled
Seth RobiaLoyola Univ. Chicago
Structure, Affinity, and Stoichiometry of Micropeptide Regulatory Complexes
Howard S. YoungUniv. of Alberta
Conformational memory in phospholamban regulation of the sarcoplasmic reticulum calcium pump SERCA
L. Michael Espinoza-FonsecaUniv. of Minnesota
Structural mechanism for SERCA uncoupling by sarcolipin through the lens of the computational microscope
Chia-chi LiuUniv. of Sydney
Silencing FXYD3 Protein in Human Pancretaic Cancer Cells Enhances Cytotoxic Effect of Doxorubicin
Alexander V ChibalinKarolinska Institute
The role of FXYD1 protein in energy metabolism

P4-ATPase (Flippase) - structure, function, cell biology and disease
September 27 (Wed), Oral session 3

Chair: Todd R. GrahamUniv. of Vanderbilt
Jens Peter AndersenUniv. of Aarhus
Mutagenesis of ATP8A2: On the track of the lipid transport pathway.
Todd R. GrahamUniv. of Vanderbilt
Novel substrates and transport mechanisms for P4-ATPases
Guillaume LenoirInstitute for Integrative Biology of the Cell
Regulation of a yeast P4-ATPase by its terminal extensions
Katsumori SegawaUniv. of Osaka
Function and regulation of plasma membrane phospholipid flippases
Hye-won ShinUniv. of Kyoto
Specific substrates for P4-ATPases and their regulation in mammalian cells
Tomoki NaitoUniv. of Kyoto
Identification of mammalian glucosylceramide flippase and its transport mechanism
Yuki HaraUniv. of Kyoto
The role of phospholipid flippase in myotube formation

Other P-type ATPases including P1, P5-ATPases
September 29 (Fri), Oral session 7

Chair: Jack KaplanUniv. of Illinois at Chicago
Jose M. ArguelloWorcester Polytechnic Institute
Expanding the repertoire of P1B-ATPases: Mycobacteria Fe2+-ATPases
Svetlana LutsenkoUniv. of Johns Hopkins
ATP7A and ATP7B have distinct function in the cellular copper homeostasis
Michael PalmgrenUniv. of Copenhagen
Evolution and role of zinc pumps in eukaryotes
David StokesUniv. of New York
Structure and Mechanism of the KdpFABC pump from E. coli
Peter VangheluweKU Leuven
Novel P-type ATPases as gatekeepers of neuronal health
Christina GronbergUniv. of Copenhagen
Ion-binding to purified and functional human copper transporting P-type ATPase ATP7B
J. Preben MorthUniv. of Oslo
Functional characterization of the first primary active magnesium transporter

Molecular simulations - towards quantitative understanding
September 27 (Wed), Oral session 4

Chair: Yuji SugitaRIKEN
Himanshu KhandeliaUniv. of Southern Denmark
The elusive proton in ion pumps
Yuji SugitaRIKEN
Molecular Dynamics Simulations of Conformational Changes in SR Ca-ATPase
Benoit RouxUniv. of Chicago
Molecular Dynamics Studies of P-type ATPase Ion Pumps

Emerging technologies
September 28 (Thu), Oral session 6

Chair: Takayuki NishizakaUniv. of Gakushuin
Takayuki NishizakaUniv. of Gakushuin
Application of single-molecule techniques to supramolecular machinery in bacteria and archaea
Rikiya WatanabeUniv. of Tokyo
Novel microsystems for highly sensitive analysis of transport proteins
Milena LabanUniv. of Aarhus
Towards a structure of the yeast lipid flippase, Drs2p/Cdc50p, using cryo-electron microscopy

Poster Sessions