Scientific Program (confirmed speakers and chairs)
Scientific sessions cover a wide range of topics in the P-type ATPase field with presentations by world leading scientists.
| Opening Remarks: | Giuseppe Inesi | California Pacific Medical Center |
| Special Lecture: | Toshio Ando | Univ. of Kanazawa |
| Nano-visualization of protein molecules in action by high-speed AFM |
| Keynote Lectures: | Poul Nissen | Univ. of Aarhus |
| Chikashi Toyoshima | Univ. of Tokyo |
Na,K-ATPase and H,K-ATPase 1 (structure-function relationship)
September 25 (Mon), Oral session 1
| Chair: Flemming Cornelius | Univ. of Aarhus |
| Kazuhiro Abe | Univ. of Nagoya |
| Structural and functional analysis of gastric H+,K+-ATPase |
| Ronald Clarke | Univ. of Sydney |
| Role of electrostatic stabilisation in the mechanism and regulation of Na+,K+- and H+,K+-ATPases |
| David Gadsby | Univ. of Rockfeller canceled |
| Proton import by Na/K pumps: evolutionary limit, or hybrid function possibly linked to neurological disorders? |
| Haruo Ogawa | Univ. of Tokyo |
| X-ray crystallographic study of Na,K-ATPase in complex with cardiotonic steroids |
| Bente Vilsen | Univ. of Aarhus |
| New aspects of sodium and potassium binding of Na,K-ATPase |
| Mads Schak Toustrup-Jensen | Univ. of Aarhus |
| Structural Elements Important for Oligomycin Inhibition of the Na+,K+-ATPase |
| Pablo Artigas | Univ. of Texas Tech |
| Effect of two asparagine-lysine substitutions found in the Na/K pump isoform unregulated in hyper salinity-adapted brine shrimp |
| Joshua R. Berlin | Univ. of Rutgers |
| Free energy calculations suggest a mechanism for Na+/K+-ATPase ion selectivity |
Na,K-ATPase and H,K-ATPase 2 (physiology and diseases)
September 28 (Thu), Oral session 5
| Chair: Kathleen Sweadner | Massachusetts General Hospital |
| Anita Aperia | Karolinska Institute |
| Neuronal Na;K-ATPase in health and disease |
| Minako Hoshi | Univ. of Kyoto |
| Na, K-ATPase ƒ¿3 and Alzheimer's Disease |
| Steve Karlish | Weizmann Institute |
| Specific interactions of Na,K-ATPase with lipids - physiological rationale and role in diseases |
| Kiyoshi Kawakami | Univ. of Jichi Medical |
| Atp1a2-deficient mice as a model of familial hemiplegic migraine |
| Helge Rasmussen | Univ. of Sydney |
| Na-K pump stimulation and FXYD3 suppression as treatment objectives in heart failure and cancer |
| Zijian Xie (Represented by Sandrine Pierre) Univ. of Marshall |
| Na/K-ATPase-mediated Signal Transduction in Animal Physiology and Disease Progression |
| Gustavo Blanco | Univ. of Kansas |
| Relative contribution of Na,K-ATPase ƒ¿4 and Na,K-ATPase ƒ¿1 isotermas to sperm motility |
| Evgeny Akkuratov | Royal Institute of Technology |
| Translational study on disease associated with mutation in ATP1A3 gene |
Ca-ATPase and other P2-ATPases
September 26 (Tue), Oral session 2
| Chair: Giuseppe Inesi | California Pacific Medical Center |
| Rajini Rao | Univ. of Johns Hopkins |
| Tumor Suppressor Role of SPCA2 in Breast Cancer |
| Hiroshi Suzuki | Univ. of Asahikawa Medical |
| Structure/function of Ca-ATPase revealed by mutations, kinetics, and structural analyses of reaction intermediates |
| David D. Thomas | Univ. of Minnesota |
| Therapeutic Discovery Based on SERCA Structural Dynamics |
| Jilin Chen | KU Leuven |
| Regulation of the secretory pathway Ca2+ ATPase SPCA1a and SPCA2 by Ca2+ and Orai1 |
Pump regulators
September 29 (Fri), Oral session 8
| Chair: Howard S. Young | Univ. of Alberta |
| Muthu Periasamy | Sunford Burnham Prebys, Medical Discovery Institute canceled |
| Seth Robia | Loyola Univ. Chicago |
| Structure, Affinity, and Stoichiometry of Micropeptide Regulatory Complexes |
| Howard S. Young | Univ. of Alberta |
| Conformational memory in phospholamban regulation of the sarcoplasmic reticulum calcium pump SERCA |
| L. Michael Espinoza-Fonseca | Univ. of Minnesota |
| Structural mechanism for SERCA uncoupling by sarcolipin through the lens of the computational microscope |
| Chia-chi Liu | Univ. of Sydney |
| Silencing FXYD3 Protein in Human Pancretaic Cancer Cells Enhances Cytotoxic Effect of Doxorubicin |
| Alexander V Chibalin | Karolinska Institute |
| The role of FXYD1 protein in energy metabolism |
P4-ATPase (Flippase) - structure, function, cell biology and disease
September 27 (Wed), Oral session 3
| Chair: Todd R. Graham | Univ. of Vanderbilt |
| Jens Peter Andersen | Univ. of Aarhus |
| Mutagenesis of ATP8A2: On the track of the lipid transport pathway. |
| Todd R. Graham | Univ. of Vanderbilt |
| Novel substrates and transport mechanisms for P4-ATPases |
| Guillaume Lenoir | Institute for Integrative Biology of the Cell |
| Regulation of a yeast P4-ATPase by its terminal extensions |
| Katsumori Segawa | Univ. of Osaka |
| Function and regulation of plasma membrane phospholipid flippases |
| Hye-won Shin | Univ. of Kyoto |
| Specific substrates for P4-ATPases and their regulation in mammalian cells |
| Tomoki Naito | Univ. of Kyoto |
| Identification of mammalian glucosylceramide flippase and its transport mechanism |
| Yuki Hara | Univ. of Kyoto |
| The role of phospholipid flippase in myotube formation |
Other P-type ATPases including P1, P5-ATPases
September 29 (Fri), Oral session 7
| Chair: Jack Kaplan | Univ. of Illinois at Chicago |
| Jose M. Arguello | Worcester Polytechnic Institute |
| Expanding the repertoire of P1B-ATPases: Mycobacteria Fe2+-ATPases |
| Svetlana Lutsenko | Univ. of Johns Hopkins |
| ATP7A and ATP7B have distinct function in the cellular copper homeostasis |
| Michael Palmgren | Univ. of Copenhagen |
| Evolution and role of zinc pumps in eukaryotes |
| David Stokes | Univ. of New York |
| Structure and Mechanism of the KdpFABC pump from E. coli |
| Peter Vangheluwe | KU Leuven |
| Novel P-type ATPases as gatekeepers of neuronal health |
| Christina Gronberg | Univ. of Copenhagen |
| Ion-binding to purified and functional human copper transporting P-type ATPase ATP7B |
| J. Preben Morth | Univ. of Oslo |
| Functional characterization of the first primary active magnesium transporter |
Molecular simulations - towards quantitative understanding
September 27 (Wed), Oral session 4
| Chair: Yuji Sugita | RIKEN |
| Himanshu Khandelia | Univ. of Southern Denmark |
| The elusive proton in ion pumps |
| Yuji Sugita | RIKEN |
| Molecular Dynamics Simulations of Conformational Changes in SR Ca-ATPase |
| Benoit Roux | Univ. of Chicago |
| Molecular Dynamics Studies of P-type ATPase Ion Pumps |
Emerging technologies
September 28 (Thu), Oral session 6
| Chair: Takayuki Nishizaka | Univ. of Gakushuin |
| Takayuki Nishizaka | Univ. of Gakushuin |
| Application of single-molecule techniques to supramolecular machinery in bacteria and archaea |
| Rikiya Watanabe | Univ. of Tokyo |
| Novel microsystems for highly sensitive analysis of transport proteins |
| Milena Laban | Univ. of Aarhus |
| Towards a structure of the yeast lipid flippase, Drs2p/Cdc50p, using cryo-electron microscopy |
Poster Sessions
